In this talk, we will explore how aging affects swallowing in Down syndrome (DS) using the Ts65Dn mouse model. DS is associated with speech and swallowing difficulties, which may become more pronounced with age. Additionally, DS is linked to Alzheimer’s disease (AD), with dysphagia being a common comorbidity. Swallowing phenotypes have been observed in the Ts65Dn mouse model of DS. This presentation will detail the effects of aging on swallowing alterations in a 20-month-old adult mouse model of DS, Ts65Dn, using Video Fluoroscopic Swallow Studies (VFSS).
Speech production errors exhibited by individuals who stutter may result from underlying deficits in auditory feedback monitoring as posited by internal models for sensorimotor processing. These deficits can lead to faulty auditory speech representations at the cortical level as the disorder progresses through its developmental course. Individuals who stutter also exhibit temporal processing deficits, which are vital for speech perception. Temporal fine structure is important for speech perception, more so in the presence of noise, as noise smears the temporal envelope of speech. Thus, deficits in temporal processing can manifest as impaired speech perception in noise in these individuals. In this talk, I will be discussing a series of behavioral and electrophysiological (frequency following responses) studies conducted to understand temporal processing in adults who stutter. These findings highlight how temporal processing and speech perception in noise are impacted in this population, warranting further exploration of these essential processes in communication.
Hearing loss is associated with negative social-emotional health outcomes, particularly increased loneliness and depression. The reasons for this are unclear. A popular theory is that hearing loss leads to an avoidance of acoustically challenging environments as well as disengagement within those environments. Over time, this social isolation can lead to increased feelings of loneliness and depression. Recent work in our lab has focused on empirically testing this theory and developing a general framework around hearing-related behaviors and their specific connections to social-emotional health outcomes. In this talk, I will first present results from a study that supports a moderated mediation model linking speech-in-noise exposure, speech perception in noise, loneliness, and depression among young adults with audiometrically normal hearing. Then, I will discuss recent evidence that shows that hearing aid use among older adults with hearing loss may be associated with increased social isolation poorer social-emotional health outcomes. The talk will conclude by discussing clinical implications for auditory rehabilitation and the need for a broader conceptualization of audiologic intervention outcomes.
This meeting will include updates on L&S annual activities, an introduction to SOCAS as a new member of the committee, a preview of potential task forces for the upcoming academic year, discussion around promoting the …
Human vocal folds are under significant phonatory stress. Common benign vocal fold mucosal pathologies can arise due to mechanical trauma. However, the underlying mechanism of how the vocal fold cells receive external mechanical forces and translate to cell response is hardly known. Piezo is a lately discovered family of mechanosensitive cation channels expressed in a wide range of mechanically sensitive tissues and cell types. In murine vocal folds, Piezo1 plays a role in murine vocal fold epithelial (re)modeling during development and after injury. The aim of this study was to investigate the biological role of Piezo1 in human vocal fold fibroblasts (hVFF). This study, in our knowledge, was the first to discover the Piezo1 channel protein in hVFF. In addition, the effect of pharmaceutical activation of the Piezo1 channel in hVFF on intracellular Ca2+ oncentration and gene expression was investigated. The long-term goal of this study is to decipher the contribution of mechanosignaling to vocal fold tissue homesotasis or disease development, so as to develop novel treatment for benign vocal fold mucosal disorders.
Cochlear implantation has become the standard of care for hearing loss not amenable to amplification by bypassing the structures of the cochlea and stimulating the spiral ganglion neurons directly. Since the first single channel electrodes were implanted, significant advancements have been made: multi-channel arrays are now standard, they are softer to avoid damage to the cochlea and pre-curved to better position the electrode array adjacent to the nerve, and surgical and stimulation techniques have helped to conform to the anatomy and physiology of the cochlea. However, even with these advances the experience does not approach that of normal hearing. In order to make significant advances in performance, the next generation of implants will require novel interface technology. Advances in regenerative techniques, optogenetics, piezoelectric materials, and bioengineered living scaffolds hold the promise for the next generation of implantable hearing devices, and hope for the restoration of natural hearing. Further, improvement in testing, predictive models, and stimulation strategies will be required to take advantage of advancements in the machine-cochlear interface.
Sound localization abilities are known to be immature at birth, and to undergo significant development during childhood. Despite a number of studies having been conducted at various ages, using various methodological approaches, there have not been systematic cross-sectional studies on localization abilities from childhood through adulthood. This is the first study to investigate those auditory spatial hearing abilities in a large cohort of typically hearing participants ranging in age from 5-24 years. The study was designed to assess the ability to discriminate between locations to the right vs. left of midline, in quiet and in the presence of a simulated echo (precedence effect). In addition, sound source identification was evaluated using a standard multi-loudspeaker array to measure sound localization error (Root-Mean-Square, RMS). This robust study will not only inform the maturation of auditory spatial hearing but will also provide a benchmark for the maturation of auditory function in individuals with hearing loss and with intellectual and developmental disabilities.