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Prosem Lecture: Aerodigestive Dysfunction in Prodromal Parkinson Disease
November 21 @ 12:00 pm - 1:00 pm
Maryann Krasko, M.S.
University of Wisconsin-Madison
Department of Communication Sciences and Disorders
Department of Surgery—Division of Otolaryngology
Topic: Aerodigestive Dysfunction in Prodromal Parkinson Disease
Parkinson disease (PD) is a whole-body neurodegenerative disorder with a complex and poorly understood etiology, and an onset of up to 20 years prior to diagnosis. This period, known as the prodrome, is overwhelmingly understudied in comparison to post-diagnostic stages, especially with regard to communication, swallowing, and gastrointestinal function. Early motor and non-motor signs like hypophonia, dysphagia, and gastrointestinal dysfunction are nearly impossible to study in humans until later in the disease process. Moreover, the inability to fully and effectively assess underlying pathology further limits our understanding of the pathophysiology in prodromal PD. Animal models are a useful tool to address some of these limitations. This talk will discuss the role of translational research, specifically the Pink1-/- rat model, and related recent findings regarding prodromal swallowing and gastrointestinal dysfunction with implications for SLP evaluation and treatment.
Funding: Maryann is a trainee on the Voice T32 training grant (T32 DC009401)