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Prosem Lecture: A Delicate Balance: Swallowing Function and Nutritional Homeostasis in ALS and Frailty

January 25 @ 12:00 pm - 1:00 pm

Presenter: Raele Donetha Robison, Ph.D., CCC-SLP, Postdoctoral Fellow, Advanced Fellowship in Women’s Health, William S. Middleton Memorial Veterans Hospital; NIH NINDS F99/K00 Scholar, Swallowing and Salivary Bioscience Laboratory, University of Wisconsin-Madison
Topic: A Delicate Balance: Swallowing Function and Nutritional Homeostasis in ALS and Frailty

Nutritional homeostasis represents the coordinated balance between energy inflow (consumption of foods and liquids) and energy outflow (energy expenditure). The oral intake of food and liquids, and thus nutritional homeostasis, relies upon intact swallowing function that is both safe (no airway invasion) and efficient (no post-swallow oropharyngeal residue). Dysphagia, or disordered swallowing, poses a potential barrier to maintaining nutritional homeostasis as individuals may be unable to consume the adequate nutrition and hydration levels necessary for optimal function and survival. In patient populations such as amyotrophic lateral sclerosis (ALS) and the frail older adults it has been suggested that homeostenosis, or the narrowing of functional reserves needed to maintain homeostasis, contributes to the development of dysphagia. However, diminished physiologic capacity and the implications of reduced functional reserve for reaching optimal swallowing function in these patient populations remains unclear. The purpose of this presentation is to provide an overview of nutritional homeostasis and the impact of homeostenosis and functional reserves on the maintenance of nutritional homeostasis. In the second part of this talk, lingual functional reserve profiles and their impact on functional aspects of swallowing in individuals with ALS will be discussed. Finally, we will conclude with a discussion of upcoming work focused on physiological changes in several functional domains that contribute to dysphagia across clinical frailty phenotypes.

Funding: R01NS100859, F99NS115339


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Details

Date:
January 25
Time:
12:00 pm - 1:00 pm
Event Category:

Venue

Online: Zoom