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Prosem Lecture: An in-vivo Approach to Understanding Vocal Communication Changes in Early-onset Parkinson Disease
November 23, 2020 @ 12:00 pm - 1:00 pm
Presenter: Cindi Kelm-Nelson, Ph.D., Associate Scientist, Department of Surgery, Division of Otolaryngology-Head and Neck Surgery
Topic: An in-vivo Approach to Understanding Vocal Communication Changes in Early-onset Parkinson Disease
Vocal communication is critical for successful social interactions, both in the human and non-human world. Communication disorders in Parkinson disease manifest in preclinical stages and negatively impact quality of life in upwards of 90% of individuals. The underlying disease pathology, including degeneration that occurs outside of the classically studied primary sensorimotor dopamine pathway, is poorly understood. The use of human subjects to address preclinical issues is impossible due to methodological limitations in experimental control and inability to collect early-stage pathologic tissue. Loss of function in the PTEN-induced kinase 1 gene (Pink1) causes an early-onset, autosomal recessive form of Parkinson disease. Modeled after this mutation, this talk will review work in rats that shows Pink1 knock-out causes: (1) vocal motor deficits that negatively impact social communication function, (2) changes to limb motor function, and (3) sex-specific onset of early other Parkinsonian signs and brainstem pathology. Further, we have shown alterations within Pink1-/- genetic profiles that alter molecular pathways in the brainstem and laryngeal muscle (thyroarytenoid). Ultimately, the results of this research platform will lead to an increased understanding of the onset of Parkinsonian behavioral phenotypes, sex differences within this genetic model, and molecular substrates that provide a scaffold for future therapeutic interventions to improve vocal function in PD.
Zoom video recording available for 7 days after the live event.
Please contact Rhonda Jacobs to get Zoom meeting details for this live event.