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Prosem Lecture: Vocal Communication and Anxiety in the Pink1-/- Rat Model of Parkinson Disease
October 21, 2019 @ 12:00 pm - 1:00 pm
Presenter: Jesse Hoffmeister, M.S., CCC-SLP, PhD Candidate, Communication Sciences and Disorders, University of Wisconsin-Madison
Topic: Vocal Communication and Anxiety in the Pink1-/- Rat Model of Parkinson Disease
Vocal communication impairment in Parkinson Disease (PD) is common, occurs early in the disease process, and has a devastating impact on quality of life and disease burden. Unfortunately, vocal impairment does not respond adequately to behavioral or medical interventions. Another “non-motor” sign of PD that occurs early in the disease process and does not respond adequately to behavioral or medical treatment is anxiety. Both vocal communication and anxiety also share neural substrates that are strongly influenced by noradrenergic mechanisms. Thus, concurrent investigation of vocal impairment and anxiety in PD may yield insights into the underlying disease-specific causes of vocal impairment and help to guide treatment. This lecture will discuss findings from a study that assays vocal communication, anxiety, and noradrenergic neural systems in the Pink1-/- rat model of PD.
NIH T32 Voice Research Training Program Pre-Doctoral Fellow