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Hearing and Donuts (Brain and Bagels) Seminar
December 2, 2022 @ 8:30 am - 9:30 am
Robert Fettiplace, Ph.D. & Maryline Beurg, Ph.D.
Department of Neuroscience, UW-Madison
Topic: The organization of the hair cell molecular force sensor.
The way in which sound vibrations are detected by cochlear hair cells has been studied for over 40 years. This process involves a mechanically sensitive ion channel to detect the movement of the hairs, but only recently has its molecular basis been elucidated. This ion channel, which has been identified as transmembrane channel-like protein, TMC1, is unique to hair cells and is the site of numerous point mutations that cause hair cell malfunction and deafness. I shall describe some of the key experiments that have led to our current understanding of the role of TMC1, including its location, ion conduction, and mechanism of activation.